LAG-3 blockade reactivates the CD8+ T cell expansion program to re-expand contracted clones in the tumor
Munetomo Takahashi, Mikiya Tsunoda, Hiroyasu Aoki, Masaki Kurosu, Haru Ogiwara, Shigeyuki Shichino, David Bending, Shumpei Ishikawa, James E. D. Thaventhiran, Kouji Matsushima, Satoshi Ueha
This study identifies a transcriptomic signature predicting CD8+ T cell clone expansion rates and shows LAG-3 blockade reactivates this signature to re-expand contracted clones in tumors.
Nature Communications · Oct 20, 2025Peer-reviewedImmunology