Kouji Matsushima

This study identifies a transcriptomic signature predicting CD8+ T cell clone expansion rates and shows LAG-3 blockade reactivates this signature to re-expand contracted clones in tumors.

The paper identifies CXCR2+ MDSC-like cells in the olfactory bulb that suppress antiviral immunity, leading to worse outcomes after VSV infection.

TAS-Seq improves scRNA-seq by enhancing gene detection and cell-cell interaction analysis in murine and human lung samples compared to existing methods.