ImmunologyNature CommunicationsPeer-reviewed
LAG-3 blockade reactivates the CD8+ T cell expansion program to re-expand contracted clones in the tumor
Munetomo Takahashi, Mikiya Tsunoda, Hiroyasu Aoki…·Satoshi Ueha
This study identifies a transcriptomic signature predicting CD8+ T cell clone expansion rates and shows LAG-3 blockade reactivates this signature to re-expand contracted clones in tumors.