James E. D. Thaventhiran

This study identifies a rare pancreatic tissue-resident regulatory T cell population that exhibits both anti-tumour and pro-repair functions in the exocrine pancreas.

This study assesses cross-neutralisation of sarbecoviruses by COVID-19 vaccines in older adults, finding reduced neutralisation of Omicron variants and some animal sarbecoviruses but enhanced neutralisation of specific bat and pangolin coronaviruses.

The paper develops a computational model to study codon decoding times, showing that near-cognate tRNAs significantly influence these times and validating the model against experimental data.

This study identifies a transcriptomic signature predicting CD8+ T cell clone expansion rates and shows LAG-3 blockade reactivates this signature to re-expand contracted clones in tumors.

This study shows human gut bacteria can accumulate PFAS, with some species like Bacteroides uniformis accumulating them to high concentrations, and identifies mechanisms involving transmembrane transport and efflux pumps.

The paper shows that parts of the TCA cycle operate in the nucleus, challenging the canonical view of metabolic compartmentalization.

The paper predicts clinically relevant variants in RAG1 and RAG2 by analyzing mutation rates and residue frequencies to identify disease-causing mutations.

The paper introduces a diagnostic gene panel called GRID for primary immunodeficiencies, showing high sensitivity and specificity in identifying genetic variants across 279 genes.