Targeting of retrovirus-derived Rtl8a/8b reduces social response and increases apathy-like behavior associated with GABRB2 reduction
Yoshifumi Fujioka, Hirosuke Shiura, Masayuki Ishii, Ryuichi Ono, Tsutomu Endo, Hiroshi Kiyonari, Yoshikazu Hirate, Hikaru Ito, Masami Kanai‐Azuma, Takashi Kohda, Tomoko Kaneko‐Ishino, Fumitoshi Ishino
This study shows that knocking out Rtl8a and Rtl8b in mice leads to reduced social behavior, increased apathy, and obesity, likely due to decreased GABRB2 expression in the brain.
bioRxiv · Aug 2, 2024 · PreprintMolecular Biology