Fumitoshi Ishino

This study identifies RTL6 as a eutherian-specific gene that regulates microglial inflammatory responses and functional state transitions through its role in LPS signaling.

This study shows PEG10-ORF1 is essential for placental labyrinth development and mid-gestational microvasculature formation in mice.

This study identifies RTL4 as a microglial gene responsive to noradrenaline, showing its expression dynamics and role in brain adaptation and neuronal network development.

This study shows that knocking out Rtl8a and Rtl8b in mice leads to reduced social behavior, increased apathy, and obesity, likely due to decreased GABRB2 expression in the brain.

This study shows that Rtl8a and Rtl8b double knockout mice develop late-onset obesity and neurodevelopmental defects, indicating these retrovirus-derived genes are important for brain function.

This study shows that disrupting the viral aspartic protease domain in PEG10 causes placental abnormalities and perinatal lethality in mice.