Distinct control of T cell proliferation and effector function by partitioning of intracellular sulfur from cysteine
Beth Kelly, Minsun Cha, Tatjana Gremelspacher, Jacob L. Martin, Massimo Andreis, Gustavo Carrizo, Mia Gidley, Michal A. Stanczak, Petya Apostolova, David E. Sanin, Ananya Majumdar, Erika L. Pearce
The paper shows that cysteine in CD8+ T cells is partitioned into glutathione and FeS-cluster synthesis, supporting effector functions and proliferation, respectively.
bioRxiv · Jan 29, 2026 · PreprintImmunology