Author

Minsun Cha

Brigham and Women's Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Benyapa KhowpinitchaiiD· 2 shared Christopher A. CassaiD· 2 shared Ersin AkıncıiD· 2 shared Grace Hui Ting YeoiD· 2 shared James D. FifeiD· 2 shared Marisa C. HamiltoniD· 2 shared Minja VelimiroviciD· 2 shared Richard I. SherwoodiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersGenetics

Benyapa KhowpinitchaiORCID

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3 papers

Recent·Most cited

Distinct control of T cell proliferation and effector function by partitioning of intracellular sulfur from cysteine

Beth Kelly, Minsun Cha, Tatjana Gremelspacher, Jacob L. Martin, Massimo Andreis, Gustavo Carrizo, Mia Gidley, Michal A. Stanczak, Petya Apostolova, David E. Sanin, Ananya Majumdar, Erika L. Pearce

The paper shows that cysteine in CD8+ T cells is partitioned into glutathione and FeS-cluster synthesis, supporting effector functions and proliferation, respectively.

bioRxiv · Jan 29, 2026 · PreprintImmunology

Systematic elucidation of genetic mechanisms underlying cholesterol uptake

Marisa C. Hamilton, James D. Fife, Ersin Akıncı, Tian Yu, Benyapa Khowpinitchai, Minsun Cha, Sammy A. Barkal, Thi Tun Thi, Grace Hui Ting Yeo, Juan Pablo Ramos Barroso, Matthew Francoeur, Minja Velimirovic, David Kenneth Gifford, Guillaume Lettre, Haojie Yu, , Richard I. Sherwood

This study identifies 21 genes whose rare variants affect LDL-C levels by altering cholesterol uptake, using CRISPR screening and co-essentiality analysis.

Cell Genomics · Apr 21, 2023Peer-reviewedGenetics

Elucidation of remdesivir cytotoxicity pathways through genome-wide CRISPR-Cas9 screening and transcriptomics

Ersin Akıncı, Minsun Cha, Lin Lin, Grace Hui Ting Yeo, Marisa C. Hamilton, Callie J. Donahue, Heysol C. Bermudez-Cabrera, Larissa Cardoso Zanetti, Maggie Chen, Sammy A. Barkal, Benyapa Khowpinitchai, Nam Ky Chu, Minja Velimirovic, Rikita Jodhani, James D. Fife, , Richard I. Sherwood

This study identifies genetic pathways involved in remdesivir cytotoxicity using CRISPR-Cas9 screening and transcriptomics, finding that SLC29A3 and AK2 are key factors in toxicity and efficacy.

bioRxiv · Aug 27, 2020 · PreprintGenetics