Optogenetic inhibition of Delta reveals digital Notch signaling output during tissue differentiation
Ranjith Viswanathan, Aleksandar Necakov, Mateusz Trylinski, Rohit Krishnan Harish, Daniel Krueger, Emilia Esposito, François Schweisguth, Pierre A. Neveu, Stefano De Renzis
This study uses optogenetic inhibition of Delta in Drosophila to show that Notch signaling exhibits digital behavior during tissue differentiation, with duration determining tissue-level responses and switch-like mechanisms at the cellular level.
EMBO Reports · Oct 31, 2019Peer-reviewedDevelopmental Biology