Aleksandar Necakov

The paper identifies HR3/RORα as a conserved cholesterol sensor that activates the TOR pathway in Drosophila and human cells, linking cholesterol availability to growth regulation.

The paper investigates the role of Notch signaling in ventral mesoderm patterning during early Drosophila embryogenesis and identifies genes regulated by this pathway.

This study uses optogenetic inhibition of Delta in Drosophila to show that Notch signaling exhibits digital behavior during tissue differentiation, with duration determining tissue-level responses and switch-like mechanisms at the cellular level.