β2 adrenergic receptors orchestrate neutrophil demargination and recruitment to the ischemic heart following myocardial infarction.
Albert Dahdah, Krishna Prahlad Maremanda, MathanKumar Marimuthu, Ki Ho Park, Robert M. Jaggers, Dipanjan Chattopadhyay, Qiang Wang, Nitin Nitin, Stavros Stavrakis, Tarun W. Dasari, Viorel Iulian Șuică, Raluca Maria Boteanu, Elena Uyy, Felicia Antohe, Douglas G. Tilley, , Prabhakara R. Nagareddy
This study identifies β2 adrenergic receptors as key regulators of neutrophil demargination and recruitment to the ischemic heart after myocardial infarction, showing that β2-AR blockers can improve cardiac remodeling.
Nature Communications · Apr 11, 2026Peer-reviewedImmunology