Andrew James Murphy

This study shows that a high PUFA diet increases PL-PUFA content in immune cells and enhances their susceptibility to ferroptosis.

This study shows cigarette smoke aggravates atherosclerosis by promoting inflammasome-primed neutrophil infiltration and impairing macrophage function through S100A8/A9 release.

This study identifies autoimmune-like CD8⁺ T cell responses as drivers of atherosclerotic plaque instability and predictors of cardiovascular events in humans and mice.

This study identifies β2 adrenergic receptors as key regulators of neutrophil demargination and recruitment to the ischemic heart after myocardial infarction, showing that β2-AR blockers can improve cardiac remodeling.

This paper shows that Disulfiram reduces cardiac inflammation and fibrosis after heart attack by inhibiting the GSDMD pathway.

This study shows that S100A8/A9 inhibition reduces splenic myelopoiesis and improves stroke outcomes by decreasing neutrophilia and infarct size.

This study shows that CASP1 self-cleavage terminates its activity in vivo, maintaining homeostasis and preventing inflammasome-driven diseases.

This study investigates the association between kynurenine and NAD+ pathway metabolites and macrophage content and polarization in carotid plaques, finding higher kynurenine levels correlate with M1 macrophages and reduced NAD+.