Prabhakara R. Nagareddy

Cigarette smoke aggravates atherosclerosis by promoting the infiltration of inflammasome-primed neutrophils and disrupting macrophage function in lesions

This study shows cigarette smoke aggravates atherosclerosis by promoting inflammasome-primed neutrophil infiltration and impairing macrophage function through S100A8/A9 release.

β2 adrenergic receptors orchestrate neutrophil demargination and recruitment to the ischemic heart following myocardial infarction.

This study identifies β2 adrenergic receptors as key regulators of neutrophil demargination and recruitment to the ischemic heart after myocardial infarction, showing that β2-AR blockers can improve cardiac remodeling.

S100A8/A9 Inhibition Reduces Splenic Myelopoiesis and Improves Outcomes After Stroke

This study shows that S100A8/A9 inhibition reduces splenic myelopoiesis and improves stroke outcomes by decreasing neutrophilia and infarct size.

Disulfiram Protects Against Diet-Induced Obesity by Reprogramming Systemic Lipid Partitioning Independent of GSDMD

This study shows Disulfiram protects against obesity and insulin resistance through GSDMD-independent mechanisms by reprogramming systemic lipid handling.

NR2F2 Reactivation in Early-life Adipocyte Stem-like Cells Rescues Adipocyte Mitochondrial Oxidation

This study shows that early-life exposure to high omega-6 fatty acids impairs adipocyte mitochondrial oxidation by suppressing NR2F2, which can be reversed by reactivating NR2F2 in stem-like cells.