Otenabant is a Selective Antagonist of Human PIEZO1
Vincent Jaquet, Reeta Penttinen, Gorane Rodríguez-Urquirizar, Cyril Castelbou, Yves Cambet, Nicolas Rosa, Mathilde Bourdin, Bita Asghariastanehei, Franciele de Lima, Marie Martin, Élie Nader, Selma Angèlica Serra, José M. Fernández‐Fernández, Nicoletta Murciano, Philippe Connes, , Nicolas Demaurex
The paper identifies Otenabant, a CB1 antagonist, as a potent and selective PIEZO1 inhibitor through high-throughput screening and validates its effects across multiple assays.
bioRxiv · Apr 30, 2026 · PreprintPharmacology & Toxicology