Author

Hélène Guizouarn

Centre National de la Recherche ScientifiqueORCID 0000-0002-8757-6672Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:electronic health records· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alexander KleseniD· 1 shared Ana Simón-ChicaiD· 1 shared Benoit AllegriniiD· 1 shared Bita Asghariastanehei· 1 shared Constanze SchmidtiD· 1 shared Cyril Castelbou· 1 shared David W. Emig· 1 shared Diana Aria· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Alexander KlesenORCID

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2 papers

Recent·Most cited

Otenabant is a Selective Antagonist of Human PIEZO1

Vincent Jaquet, Reeta Penttinen, Gorane Rodríguez-Urquirizar, Cyril Castelbou, Yves Cambet, Nicolas Rosa, Mathilde Bourdin, Bita Asghariastanehei, Franciele de Lima, Marie Martin, Élie Nader, Selma Angèlica Serra, José M. Fernández‐Fernández, Nicoletta Murciano, Philippe Connes, , Nicolas Demaurex

The paper identifies Otenabant, a CB1 antagonist, as a potent and selective PIEZO1 inhibitor through high-throughput screening and validates its effects across multiple assays.

bioRxiv · Apr 30, 2026 · PreprintPharmacology & Toxicology

Piezo1 and BKCa channels in human atrial fibroblasts: interplay and remodelling in atrial fibrillation

Dorothee Jakob, Alexander Klesen, Benoit Allegrini, Elisa Darkow, Diana Aria, David W. Emig, Ana Simón-Chica, Eva A. Rog-Zielinska, Tim Guth, Friedhelm Beyersdorf, Fabian Alexander Kari, Susanne Proksch, Stéphane N. Hatem, Matthias Karck, Stephan R. Künzel, , Rémi Peyronnet

This study identifies two stretch-activated ion channels, Piezo1 and BKCa, in human atrial fibroblasts and shows their differential regulation in atrial fibrillation.

EP Europace · May 1, 2021Peer-reviewedMolecular Biology