Discovery of Tcf7 regulators with clonally-resolved CRISPR screens identifies Trim28 as a mediator of CD8 T cell differentiation in tumors
Marc A. Schwartz, Dillon Lue, Mohammed Mutaher, Miriam McNerney, Oluwatomisin Olajide, Arnav Mehta, Jared H. Rowe, Ryan Jin-hyung Park, Mohsen Malehmir, Juan Dubrot, Aziz M. Al’Khafaji, Matt Bakalar, Lynn Bi, Martin W. LaFleur, Kathleen B. Yates, , Nir Hacohen
The paper identifies Trim28 as a regulator of CD8 T cell differentiation in tumors using clonally-resolved CRISPR screens and shows its role in maintaining TCF7+ stem-like cells while impairing effector differentiation.
bioRxiv · Jun 17, 2026 · PreprintImmunology