Author

Arlene H. Sharpe

Broad InstituteORCID 0000-0002-9736-2109Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Approach:benchmark study· 1

Frequent Co-Authors

Amy Y. HuangiD· 2 shared Emily J. RobitschekiD· 2 shared Jared H. RoweiD· 2 shared Alex Bastian· 1 shared Arnav MehtaiD· 1 shared Aziz M. Al’KhafajiiD· 1 shared Brian C. MilleriD· 1 shared Cassia Wang· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

Amy Y. HuangORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Depletion of extracellular asparagine impairs self-reactive T cells and ameliorates autoimmunity in a murine model of multiple sclerosis

Peter Georgiev, Sheila E. Johnson, Kiran Kurmi, Song-Hua Hu, SeongJun Han, Dillon G. Patterson, Thao H. Nguyen, Linglin Huang, Dan Liang, Naomi Goldman, Thomas S. Conway, Hannah Creasey, Jared H. Rowe, Marcia C. Haigis, Arlene H. Sharpe

eLife · Jul 8, 2026Peer-reviewedImmunology

Discovery of Tcf7 regulators with clonally-resolved CRISPR screens identifies Trim28 as a mediator of CD8 T cell differentiation in tumors

Marc A. Schwartz, Dillon Lue, Mohammed Mutaher, Miriam McNerney, Oluwatomisin Olajide, Arnav Mehta, Jared H. Rowe, Ryan Jin-hyung Park, Mohsen Malehmir, Juan Dubrot, Aziz M. Al’Khafaji, Matt Bakalar, Lynn Bi, Martin W. LaFleur, Kathleen B. Yates, , Nir Hacohen

The paper identifies Trim28 as a regulator of CD8 T cell differentiation in tumors using clonally-resolved CRISPR screens and shows its role in maintaining TCF7+ stem-like cells while impairing effector differentiation.

bioRxiv · Jun 17, 2026 · PreprintImmunology

Harnessing Inflammatory Monocytes to Overcome Resistance to Anti-PD-1 Immunotherapy

Matthew P. Zimmerman, Amy Y. Huang, Emily K. Cox, Rose Al Abosy, Wan Lin Chong, Alex Bastian, Katherine J. Vietor, Yacine A. Choutri, Jenna L. Collier, Vasyl Zhabotynsky, Haiyang Wang, Megan E. Fung, Sarah A. Weiss, Emily J. Robitschek, Jia‐Ren Lin, , Brian C. Miller

This study shows CD40 agonist therapy reduces tumor growth in antigen presentation-deficient tumors by reprogramming monocytes and requiring IFN-gamma and CD8+ T cells for efficacy.

bioRxiv · Feb 8, 2026 · PreprintImmunology

Stratified analysis identifies HIF-2α as a therapeutic target for highly immune-infiltrated melanomas

Amy Y. Huang, Kelly P. Burke, Ryan M. Porter, Lynn Meiger, Peter R. Fatouros, Jiekun Yang, Emily J. Robitschek, Natalie I. Vokes, Cora A. Ricker, Valeria Rosado, Giuseppe Tarantino, Jiajia Chen, Tyler J. Aprati, Marc Glettig, Yiwen He, , David Liu

The paper identifies HIF-2α as a therapeutic target for immune-infiltrated melanomas through stratified analysis of clinical and molecular data.

bioRxiv · Oct 29, 2024 · PreprintCancer Biology