Mohammed Mutaher

This study shows folate deprivation impairs CD8+ T cell function by disrupting cell surface glycosylation, and increasing folate uptake enhances T cell anti-tumor activity.

The paper identifies Trim28 as a regulator of CD8 T cell differentiation in tumors using clonally-resolved CRISPR screens and shows its role in maintaining TCF7+ stem-like cells while impairing effector differentiation.

The paper presents a machine learning challenge to predict gene perturbation effects on T cell differentiation, finding that feature representation from perturbational data improves performance and validating top genes experimentally.