Author

Matthew Chagnon

Massachusetts Eye and Ear Infirmary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Anil K. ChekuriiD· 2 shared Elisabetta MoriniiD· 2 shared Luk H. VandenbergheiD· 2 shared Susan A. SlaugenhauptiD· 2 shared Swanand KoliiD· 2 shared Caitlin Elizabeth Keiper· 1 shared Dadi GaoiD· 1 shared Drenushe Krasniqi· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenetics

Anil K. ChekuriORCID

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2 papers

Recent·Most cited

ELP1 Gene Augmentation Restores Visual Function in a Mouse Model of Familial Dysautonomia

Hui‐Chen Cheng, Swanand Koli, Kate J. Lewis, Sara Ketchale, Yasaman Anvarinia, Morgan P. Erdoes, Yating Liu, Caitlin Elizabeth Keiper, Reynette Estelien, Matthew Chagnon, Luk H. Vandenberghe, Dadi Gao, Frances B. Lefcort, Elisabetta Morini, Susan A. Slaugenhaupt, Anil K. Chekuri

This study shows that gene supplementation with ELP1 in a mouse model of familial dysautonomia rescues retinal structure and function, suggesting it as a potential therapy for FD-associated optic neuropathy.

Molecular Therapy · Apr 25, 2026Peer-reviewedGenetics

AAV2-mediated intravitreal delivery of exon-specific U1 snRNA rescues optic neuropathy in a mouse model of familial dysautonomia.

Anil K. Chekuri, Krishnakanth Kondabolu, Emily G. Kirchner, Swanand Koli, Matthew Chagnon, Drenushe Krasniqi, Max E. Stern, Jessica Bolduc, Giulia Romano, Franco Pagani, Luk H. Vandenberghe, Elisabetta Morini, Susan A. Slaugenhaupt

This study uses AAV2-delivered exon-specific U1 snRNA to correct ELP1 splicing and rescue optic neuropathy in a FD mouse model.

Molecular Therapy — Nucleic Acids · Dec 10, 2025Peer-reviewedMolecular Biology