Author

Jessica Bolduc

Massachusetts General Hospital

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2 Developmental Biology· 1 Genetics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Anil K. ChekuriiD· 4 shared Elisabetta MoriniiD· 4 shared Emily G. KirchneriD· 4 shared Emily M. Logan· 3 shared Monica Salani· 3 shared Susan Slaugenhaupt· 3 shared Aram J. KrausoniD· 2 shared Luk H. VandenbergheiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersMolecular Biology

Anil K. ChekuriORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Genomic analysis of BCG unresponsive non-muscle-invasive bladder cancer identifies drivers of sensitivity to intravesical Gemcitabine/Docetaxel

Kendrick H. Yim, Matías Vergara, Jihyun Lee, Brendan Michael Reardon, J Park, Kevin Richard Melnick, Timothy N. Clinton, Matthew Mossanen, Graeme S. Steele, Jessica Bolduc, Michelle S. Hirsch, Natalie M. Rizzo, Chin‐Lee Wu, Matthew F. Wszolek, Keyan Salari, , Filipe L.F. Carvalho

The paper identifies genomic features associated with response or resistance to Gem/Doce in BCG-unresponsive NMIBC using whole-exome sequencing and phylogenetic analysis.

bioRxiv · May 18, 2026 · PreprintGenomics

AAV2-mediated intravitreal delivery of exon-specific U1 snRNA rescues optic neuropathy in a mouse model of familial dysautonomia.

Anil K. Chekuri, Krishnakanth Kondabolu, Emily G. Kirchner, Swanand Koli, Matthew Chagnon, Drenushe Krasniqi, Max E. Stern, Jessica Bolduc, Giulia Romano, Franco Pagani, Luk H. Vandenberghe, Elisabetta Morini, Susan A. Slaugenhaupt

This study uses AAV2-delivered exon-specific U1 snRNA to correct ELP1 splicing and rescue optic neuropathy in a FD mouse model.

Molecular Therapy — Nucleic Acids · Dec 10, 2025Peer-reviewedMolecular Biology

Transcriptome analysis in a humanized mouse model of familial dysautonomia reveals tissue-specific gene expression disruption in the peripheral nervous system.

Ricardo Harripaul, Elisabetta Morini, Monica Salani, Emily M. Logan, Emily G. Kirchner, Jessica Bolduc, Anil K. Chekuri, Benjamin Currall, Rachita Yadav, Serkan Erdin, Michael E. Talkowski, Dadi Gao, Susan Slaugenhaupt

This study uses transcriptome analysis in a humanized mouse model of FD to identify tissue-specific gene expression disruptions in the peripheral nervous system.

Scientific Reports · Jan 4, 2024Peer-reviewedGenomics

Development of a novel oral treatment that rescues gait ataxia and retinal degeneration in a phenotypic mouse model of familial dysautonomia.

Elisabetta Morini, Anil K. Chekuri, Emily M. Logan, Jessica Bolduc, Emily G. Kirchner, Monica Salani, Aram J. Krauson, Jana Narasimhan, Vijayalakshmi Gabbeta, Shivani Grover, Amal Dakka, Anna Mollin, Stephen P. Jung, Xin Zhao, Nanjing Zhang, , Susan Slaugenhaupt

This paper develops an oral treatment, PTC258, that restores ELP1 splicing and improves symptoms in a mouse model of familial dysautonomia.

The American Journal of Human Genetics · Feb 20, 2023Peer-reviewedGenetics

16p12.1 deletion orthologs are expressed in motile neural crest cells and are important for regulating craniofacial development in Xenopus laevis

Micaela C. Lasser, Jessica Bolduc, Luke Murphy, Caroline O’Brien, Sangmook Lee, Santhosh Girirajan, Laura Anne Lowery

This study investigates the role of 16p12.1 deletion orthologs in craniofacial development by analyzing their expression and function in Xenopus laevis neural crest cells.

Frontiers in Genetics · Mar 24, 2022Peer-reviewedDevelopmental Biology

Selective retinal ganglion cell loss and optic neuropathy in a humanized mouse model of familial dysautonomia

Anil K. Chekuri, Emily M. Logan, Aram J. Krauson, Monica Salani, Sophie Ackerman, Emily G. Kirchner, Jessica Bolduc, Xia Wang, Paula Dietrich, Ioannis Dragatsis, Luk H. Vandenberghe, Susan Slaugenhaupt, Elisabetta Morini

This study characterizes retinal degeneration in a humanized mouse model of familial dysautonomia and shows that the splicing modulator BPN-15477 can correct the ELP1 splicing defect in the retina.

Human Molecular Genetics · Dec 13, 2021Peer-reviewedNeuroscience