Cross-Platform Assessment of Sub-50 nm Nanopipette Emitters for Native Electrospray Ionization Mass Spectrometry
Emily J. Byrd, Eileen J. Olivares, Zoe J Heidersbach, Raya Sadighi, Khaled Madhoun, Iris Ansah, Matthew J. Kensil, Luchen Wuyang, Rafael Donadelli Melani, Paolo Actis, Joseph A. Loo, Frank Sobott, Kevin J. Freedman, Pei Su, Anouk M. Rijs, Antonio N. Calabrese
This study benchmarks sub-50 nm quartz nanopipette emitters for native electrospray ionization mass spectrometry across multiple platforms and protein sizes, showing improved signal-to-noise and reduced adduction.
bioRxiv · Aug 18, 2026 · PreprintBiochemistry