Author

Matthew Jefferson

University of East Anglia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Gen YoshiiiD· 1 shared Hiroki Nakanishi· 1 shared Kentaro TomiiiD· 1 shared Maria SakuraiiD· 1 shared Shoichi SuenagaiD· 1 shared Takeshi IwatsuboiD· 1 shared Thomas E. WilemaniD· 1 shared Tomoki KuwaharaiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperCell Biology

Gen YoshiiORCID

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1 paper

Recent·Most cited

PIKfyve inhibition induces LRRK2 activation through phosphatidylinositol 3-phosphate and CASM

Tomoki Kuwahara, Gen Yoshii, Maria Sakurai, Shoichi Suenaga, Hiroki Nakanishi, Matthew Jefferson, Thomas E. Wileman, Kentaro Tomii, Takeshi Iwatsubo

This study shows that PIKfyve inhibition leads to LRRK2 hyperactivation through PI3P and CASM, revealing a new mechanism involving membrane lipids and Rab proteins.

bioRxiv · Dec 18, 2025 · PreprintCell Biology