Gen Yoshii

This study shows that PIKfyve inhibition leads to LRRK2 hyperactivation through PI3P and CASM, revealing a new mechanism involving membrane lipids and Rab proteins.

This study identifies the V-ATPase-ATG16L1 axis as a mechanism recruiting LRRK2 to stressed lysosomes, facilitating lysosomal stress responses independent of canonical autophagy.

The paper investigates how lysosomotropic agents enhance LRRK2-mediated Rab10 phosphorylation under lysosomal stress conditions.