Tomoki Kuwahara

This study identifies a novel STING-induced pathway involving LRRK2 that drives pericentrosomal positioning of acidic organelles through the VAIL-LRRK2-Rab35 mechanism.

This study shows that PIKfyve inhibition leads to LRRK2 hyperactivation through PI3P and CASM, revealing a new mechanism involving membrane lipids and Rab proteins.

This study identifies the V-ATPase-ATG16L1 axis as a mechanism recruiting LRRK2 to stressed lysosomes, facilitating lysosomal stress responses independent of canonical autophagy.

The paper identifies a novel phosphorylation of Rab29 at Ser185, mediated by PKC, which regulates its localization and lysosomal stress response in conjunction with LRRK2.

The paper investigates how lysosomotropic agents enhance LRRK2-mediated Rab10 phosphorylation under lysosomal stress conditions.