Thomas E. Wileman

PIKfyve inhibition induces LRRK2 activation through phosphatidylinositol 3-phosphate and CASM

This study shows that PIKfyve inhibition leads to LRRK2 hyperactivation through PI3P and CASM, revealing a new mechanism involving membrane lipids and Rab proteins.

ATG16L1 WD domain regulates lipid trafficking to maintain plasma membrane integrity to limit influenza virus infection

The V-ATPase-ATG16L1 axis recruits LRRK2 to facilitate lysosomal stress responses

This study identifies the V-ATPase-ATG16L1 axis as a mechanism recruiting LRRK2 to stressed lysosomes, facilitating lysosomal stress responses independent of canonical autophagy.

Regulatory network analysis of Paneth cell and goblet cell enriched gut organoids using transcriptomics approaches

The paper uses transcriptomics and network analysis to study regulatory networks in Paneth and goblet cell enriched gut organoids, identifying key regulators and their links to inflammatory bowel disease.

Integrative analysis of Paneth cell proteomic and transcriptomic data from intestinal organoids reveals functional processes dependent on autophagy

The paper integrates proteomic and transcriptomic data from intestinal organoids to identify autophagy-dependent processes in Paneth cells, showing that autophagy impairment affects protein abundance and key cellular functions.