Takeshi Iwatsubo

This study identifies a novel STING-induced pathway involving LRRK2 that drives pericentrosomal positioning of acidic organelles through the VAIL-LRRK2-Rab35 mechanism.

This study shows that PIKfyve inhibition leads to LRRK2 hyperactivation through PI3P and CASM, revealing a new mechanism involving membrane lipids and Rab proteins.

The paper identifies APOE rare missense variants in the Japanese population and finds two variants associated with protective effects against Alzheimer's disease.

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

This study identifies the V-ATPase-ATG16L1 axis as a mechanism recruiting LRRK2 to stressed lysosomes, facilitating lysosomal stress responses independent of canonical autophagy.

The paper identifies a novel phosphorylation of Rab29 at Ser185, mediated by PKC, which regulates its localization and lysosomal stress response in conjunction with LRRK2.

The paper investigates how lysosomotropic agents enhance LRRK2-mediated Rab10 phosphorylation under lysosomal stress conditions.

The paper shows that CREST toxicity in yeast and flies is reduced by PBP1/ATXN2 deletion, suggesting ATXN2 as a therapeutic target for ALS.