Multi-omic Evaluations Nominate an ER-Mitochondrial Axis and Inflammatory Macrophage as Drivers of Right Atrial Dysfunction
Jenna B. Mendelson, Jacob D. Sternbach, Jeffrey C. Blake, Minwoo Kim, Ryan A. Moon, Rashmi M. Raveendran, Lynn M. Hartweck, Walt Tollison, Matthew Lahiri, John P. Carney, Todd W. Markowski, LeeAnn Higgins, Cutler T. Lewandowski, Felipe Kazmirczak, Gaurav Choudhary, Kurt W. Prins
This study identifies ER-mitochondrial dysfunction and inflammatory macrophages as drivers of right atrial dysfunction using multi-omic analyses in a pulmonary artery banded swine model.
bioRxiv · Mar 22, 2025 · PreprintPhysiology