John P. Carney

Proteomics Defines Shared and Divergent Alterations in the Right Atrium and Right Ventricle in Porcine Right Heart Failure

The paper uses proteomics to compare alterations in the right atrium and right ventricle of pigs with right heart failure, identifying shared and distinct metabolic changes.

Multimodality Molecular Profiling Nominates Targetable Mechanisms in Progressive RV Dysfunction

This study uses multi-omics profiling to identify molecular mechanisms contributing to progressive right ventricular dysfunction in pigs.

Multi-omic Evaluations Nominate an ER-Mitochondrial Axis and Inflammatory Macrophage as Drivers of Right Atrial Dysfunction

This study identifies ER-mitochondrial dysfunction and inflammatory macrophages as drivers of right atrial dysfunction using multi-omic analyses in a pulmonary artery banded swine model.

17β-Estradiol Counteracts Pathological Microtubule Remodeling To Enhance Cardiac Function

This study shows 17β-estradiol counteracts pathological microtubule remodeling in cardiomyocytes, improving cardiac function and preventing cellular hypertrophy and structural abnormalities.

Glycoprotein 130 Antagonism Counteracts Metabolic and Inflammatory Alterations to Enhance Right Ventricle Function in Pulmonary Artery Banded Pigs

SC144 improves right ventricular function in pulmonary artery banded pigs by reducing inflammation, restoring metabolism, and enhancing cell communication.

Ferroptosis Inhibition Combats Metabolic Derangements and Improves Cardiac Function in Pulmonary Artery Banded Pigs

This study shows ferroptosis inhibition improves cardiac function and metabolism in a large animal model of right heart failure.