Author

Matthew Manh Nguyen

University of Washington

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Molecular Biology· 1

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Approach:experimental assay· 1 Organism:human· 1

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Crina CurcaiD· 1 shared Julia M. SidorovaiD· 1 shared Junko OshimaiD· 1 shared Maria N. Pavlova· 1 shared Pavlo Lazarchuk· 1 shared

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1 paper

Recent·Most cited

Molecular BiologyAgingPeer-reviewedOct 17, 2024

Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells

Pavlo Lazarchuk, Matthew Manh Nguyen, Crina Curca…·Julia M. Sidorova

This study shows WRN helicase maintains constitutive heterochromatin in human fibroblasts by interacting with HDAC2 and HP1, and its loss disrupts heterochromatin structure and LBR expression, contributing to aging and senescence.

3 citations

humanexperimental assay

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