Author

Crina Curca

University of WashingtonORCID 0009-0005-7594-2144Unclaimed ORCID profile · follow to get notified of new preprints

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Crina Curca1 paper

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Molecular Biology· 1

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Approach:experimental assay· 1 Organism:human· 1

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Julia M. SidorovaiD· 1 shared Junko OshimaiD· 1 shared Maria N. Pavlova· 1 shared Matthew Manh Nguyen· 1 shared Pavlo Lazarchuk· 1 shared

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Julia M. SidorovaORCID

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Molecular BiologyAgingPeer-reviewedOct 17, 2024

Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells

Pavlo Lazarchuk, Matthew Manh Nguyen, Crina Curca…·Julia M. Sidorova

This study shows WRN helicase maintains constitutive heterochromatin in human fibroblasts by interacting with HDAC2 and HP1, and its loss disrupts heterochromatin structure and LBR expression, contributing to aging and senescence.

3 citations

humanexperimental assay

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