Molecular BiologyAgingPeer-reviewed
Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells
Pavlo Lazarchuk, Matthew Manh Nguyen, Crina Curca…·Julia M. Sidorova
This study shows WRN helicase maintains constitutive heterochromatin in human fibroblasts by interacting with HDAC2 and HP1, and its loss disrupts heterochromatin structure and LBR expression, contributing to aging and senescence.
3 citations