Julia M. Sidorova

This study shows WRN helicase maintains constitutive heterochromatin in human fibroblasts by interacting with HDAC2 and HP1, and its loss disrupts heterochromatin structure and LBR expression, contributing to aging and senescence.

The paper identifies host proteins modulating SARS-CoV-2 infection by expanding the virus-host protein interaction network and testing chemical inhibitors of these targets.

This study shows that STING modulates nascent DNA degradation at stalled replication forks, linking replication stress to innate immunity.