Author

Matthew Willetts

Bruker (United States)Primary ORCID profile (0000-0001-6585-3950 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Matthew WillettsiD1 paper · University of Oxford

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Approach:deep learning· 1

Frequent Co-Authors

Ajay BhardwajiD· 1 shared Aleksandr B. StotlandiD· 1 shared Aleksandra BinekiD· 1 shared Allison L. HuntiD· 1 shared Andrew LeduciD· 1 shared Arun SharmaiD· 1 shared Aswini PanigrahiiD· 1 shared Bhaskar KallakuryiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperMolecular Biology

Ajay BhardwajORCID

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3 papers

Recent·Most cited

Expanded Proteome Coverage Powered by Advanced Ion Processing Enables Deep Single-Cell Drug Response Subtyping in Human Stem Cell Derived Cardiomyocytes

Johannes V. Janssens, Aleksandra Binek, Lizhuo Ai, Ajay Bhardwaj, Madelyn Arzt, Diego Assis, Matthew Willetts, Michael Krawitzky, Daniel Hornburg, Arun Sharma, Aleksandr B. Stotland, Jennifer E. Van Eyk

This paper introduces an enhanced single-cell proteomics workflow using timsUltra AIP, showing improved proteome coverage and drug response subtyping in human iPSC-CMs.

bioRxiv · May 31, 2026 · PreprintMolecular Biology

dia-PASEF Proteomics of Tumor and Stroma LMD Enriched from Archived HNSCC Samples

Aswini Panigrahi, Allison L. Hunt, Diego M. Assis, Matthew Willetts, Bhaskar Kallakury, Bruce J. Davidson, Jaeil Ahn, Thomas P. Conrads, Radoslav Goldman

The paper uses laser microdissection and proteomics to compare tumor and stroma in HNSCC tissues, identifying ECM enrichment in stroma and potential targets for disease intervention.

ACS Omega · Mar 25, 2025Peer-reviewedCancer Biology

Increasing the throughput of sensitive proteomics by plexDIA

Jason Derks, Andrew Leduc, Georg Wallmann, R. Gray Huffman, Matthew Willetts, Saad Khan, Harrison Specht, Markus Ralser, Vadim Demichev, Nikolai Slavov

Multiplexing nonisobaric isotopologous mass tags (mTRAQ) with data-independent acquisition and DIA-NN increases sensitive proteomics throughput 3-fold while cutting missing data below 3% in bulk and single cells.

Nature Biotechnology · Jul 14, 2022Peer-reviewedBioengineering✦ In-depth digest