Aleksandr B. Stotland

This paper introduces an enhanced single-cell proteomics workflow using timsUltra AIP, showing improved proteome coverage and drug response subtyping in human iPSC-CMs.

This study investigates the protective effects of ASPN in cardiac myocytes under ischemia-reperfusion stress using an in vitro model, finding it modulates apoptosis, autophagy, and fibrosis-related pathways.

This study identifies CNPY4 as a sphingolipid-binding protein that regulates sphingolipid levels and distribution, impacting cholesterol homeostasis and cellular signaling.

This study shows chronic IFN exposure impairs heart function by causing mitochondrial stress, mtDNA release, and a self-sustaining inflammatory loop in cardiomyocytes.

This paper develops a rapid proteomics method using HTA protease and LC-MS to quantify blood biomarkers in under an hour.

The paper develops methods to detect glycophagy in cardiac cells using antibodies and fluorescent markers to measure lysosomal flux and glycogen accumulation.

This paper introduces a high-throughput proteomics workflow using Orbitrap and Astral mass analyzers, demonstrating robust sample preparation and high protein identification rates across diverse biological samples.

This study adapts high-field asymmetric ion mobility spectrometry (FAIMS) coupled with mass spectrometry to improve cardiac muscle proteome coverage with reduced sample handling and processing time compared to traditional methods.

This study identifies sex-based proteomic differences in iPSC-derived vascular smooth muscle cells and their potential impact on cardiovascular disease.

This study identifies Gabarapl1 as a regulator of glycophagy in diabetic cardiomyopathy, showing its role in preventing glycogen accumulation and diastolic dysfunction.

MitoPlex is a targeted MS assay for quantifying 37 mitochondrial proteins, paired with a metabolite assay, showing statin effects on mitochondrial function in different tissues.