Macrophages restrict tumor permissiveness to immune infiltration by controlling local collagen topography through a Tcf4-Collagen3 fibrotic axis
Zoé Fusilier, Franck Simon, Isabel Calvente, Lou Crestey, Alexandra Clément, Mathilde Mathieu, Roude Jean-Marie, Florence Piastra-Facon, Jeyani George Clément, Enola Lumineau, Mattia Tonani, Valeria Manriquez, Lívia Lacerda Mariano, Perrine de Villemagne, Eliane Piaggio, , Hélène D. Moreau
This study shows that macrophages control collagen network topography via Tcf4-Collagen3 pathway, influencing immune cell infiltration in tumors.
bioRxiv · Jan 17, 2025 · PreprintImmunology