Dual PD-L1/TIGIT blockade induces PNAd+ HEV-like vessels and CD62L+ lymphocyte recruitment, driving rhabdoid tumor rejection
Stéphanie Fitte-Duval, S Silva, Rafael Mena‐Osuna, Owen Hoare, Leticia Laura Niborski, Jordan Denizeau, Laëtitia Lesage, Wilfrid Richer, Christine Sedlik, Kévin Beccaria, Maëva Veyssière, Rachida Bouarich-Bourimi, Jérémie D. Goldstein, Federico Marziali, Jimena Tosello, , Eliane Piaggio
This study shows that combining PD-L1 and TIGIT blockade in a mouse model of rhabdoid tumors leads to tumor regression by promoting immune cell recruitment and vascular changes.
bioRxiv · Dec 17, 2025 · PreprintImmunology