Franck Simon

Label-free Machine Learning Prediction of Chemotherapy on Tumor Spheroids using a Microfluidics Droplet Platform

This paper develops a label-free platform combining microfluidics, morphological analysis, and machine learning to predict chemotherapy effects on tumor spheroids, showing robust performance across cell lines and patient-derived samples.

CausalXtract: a flexible pipeline to extract causal effects from live-cell time-lapse imaging data

CausalXtract identifies causal effects in live-cell imaging data by combining network and information-based frameworks, revealing novel interactions in tumor-on-chip systems.

Macrophages restrict tumor permissiveness to immune infiltration by controlling local collagen topography through a Tcf4-Collagen3 fibrotic axis

This study shows that macrophages control collagen network topography via Tcf4-Collagen3 pathway, influencing immune cell infiltration in tumors.