Maximilian Haas

A homozygous human WNT11 loss-of-function variant associated with laterality, heart and renal defects

The paper identifies a homozygous WNT11 variant causing laterality, heart, and renal defects in an infant and shows its loss-of-function in Xenopus embryos.

Temporal Notch signaling and Hes-mediated competitive de-repression regulate mucociliary cell fates in Xenopus

The paper investigates how Notch signaling and Hes factors regulate mucociliary cell fate specification in Xenopus tadpole epidermis through competitive de-repression.

A changing signaling environment induces multiciliated cell trans-differentiation during developmental remodeling

The paper shows that multiciliated cells can trans-differentiate into secretory cells during developmental remodeling in Xenopus, induced by changes in signaling pathways.

ΔN-Tp63 mediates Wnt/β-catenin-induced inhibition of differentiation in basal stem cells of mucociliary epithelia

This study identifies ΔN-Tp63 as a key mediator of Wnt/β-catenin signaling in basal stem cells of mucociliary epithelia, showing its role in inhibiting differentiation and promoting hyperplasia.