The spatial landscape of glial pathology and T-cell response in Parkinson's disease substantia nigra
Maxwell Ma, Fahad Paryani, Kelly A. Jakubiak, Shengnan Xia, Susumu Antoku, Adithya Kannan, Jaeseung Lee, Nacoya Madden, Shailesh Senthil Kumar, Juncheng Li, David Chen, Gunnar Hargus, Aayushi Mahajan, Xena E. Flowers, Ashley S. Harms, , Osama Al‐Dalahmah
The paper analyzes T-cell responses and glial pathology in Parkinson's disease substantia nigra using single nucleus RNA sequencing and spatial transcriptomics, revealing CD8+ T-cell characteristics and altered cellular interactions.
Nature Communications · Aug 4, 2025Peer-reviewedNeuroscience