Osama Al‐Dalahmah

The human-specific lncRNA HD-LINC drives lipid droplet-associated neurodegeneration in Huntington's disease

This study identifies HD-LINC, a human-specific lncRNA, as a driver of lipid droplet-associated neurodegeneration in Huntington's disease, showing its role in lipid metabolism and neuronal death.

Stage-Specific NF-κB RelA and IRF4 Programs Drive -Synuclein-Induced Disease-Associated Microglia Differentiation

This study identifies NF-κB RelA and IRF4 as stage-specific regulators driving -synuclein-induced disease-associated microglia differentiation in Parkinson disease.

Paired Tumor Biopsies Reveal Spatiotemporal Myeloid Remodeling After Local Chemotherapy in Glioblastoma

This study examines the spatiotemporal myeloid response to chemotherapy in glioblastoma using multiple models, showing chemotherapy-induced genotoxic stress and inflammatory remodeling in myeloid cells.

Electrophysiologically Targeted Biopsies Reveal the Transcriptional Landscape of Focal Epilepsy

This study uses electrophysiologically guided biopsies and single-nucleus RNA sequencing to identify transcriptional differences between seizure focus and ictal penumbra in focal epilepsy.

The spatial landscape of glial pathology and T-cell response in Parkinson's disease substantia nigra

The paper analyzes T-cell responses and glial pathology in Parkinson's disease substantia nigra using single nucleus RNA sequencing and spatial transcriptomics, revealing CD8+ T-cell characteristics and altered cellular interactions.

Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte state

This study uses multi-omic analysis to identify a neuroprotective astrocyte state in Huntington disease that correlates with delayed disease onset and neuroprotection.

Single nuclei RNAseq analysis of HD mouse models and human brain reveals impaired oligodendrocyte maturation and potential role for thiamine metabolism

This study uses snRNAseq to analyze HD mouse models and human brain tissue, identifying impaired oligodendrocyte maturation and a potential role for thiamine metabolism in disease pathology.

Single-nucleus RNA-seq identifies Huntington disease astrocyte states

This study uses snRNA-seq to identify distinct transcriptional states of astrocytes in Huntington disease, revealing gene expression changes compared to controls.