Fahad Paryani

This study identifies impaired glial-mediated synaptic refinement in FXS model mice, showing enhanced astrocyte-microglia signaling and synaptic over-engulfment as key features.

The paper analyzes T-cell responses and glial pathology in Parkinson's disease substantia nigra using single nucleus RNA sequencing and spatial transcriptomics, revealing CD8+ T-cell characteristics and altered cellular interactions.

The paper identifies cell-type-specific and continuous gene programs associated with Alzheimer's Disease across multiple racial and ethnic groups using single-nucleus RNA-seq and ATAC-seq.

This study uses multi-omic analysis to identify a neuroprotective astrocyte state in Huntington disease that correlates with delayed disease onset and neuroprotection.

This study uses snRNAseq to analyze HD mouse models and human brain tissue, identifying impaired oligodendrocyte maturation and a potential role for thiamine metabolism in disease pathology.