Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model
Mariah L. Hoye, Lorenzo Calviello, Abigail Poff, Emeka Ejimogu, Carly R Newman, Maya D Montgomery, Jianhong Ou, Stephen N. Floor, Debra L. Silver
This study investigates DDX3X syndrome using a mouse model, showing that DDX3X regulates cell cycle and translation in neural progenitors, leading to cortical malformations and neurodevelopmental issues.
eLife · May 25, 2022Peer-reviewedDevelopmental Biology