Mariah L. Hoye

The paper shows miR-146a regulates multiple aspects of motor neuron degeneration in ALS, with genetic deletion extending survival and causing age-related paralysis and inflammation.

The paper identifies GC content in coding sequences as a key factor in mRNA stabilization following DDX3X depletion, supported by analysis of RNA-seq data and ENCODE datasets.

This study investigates DDX3X syndrome using a mouse model, showing that DDX3X regulates cell cycle and translation in neural progenitors, leading to cortical malformations and neurodevelopmental issues.

This study identifies DDX3X mutations as causing neurodevelopmental disorders by disrupting RNA metabolism and neurogenesis during fetal cortical development.