Jianhong Ou

Microenvironmental and transcriptional determinants of the robustness of spinal cord regeneration in zebrafish

The paper identifies hoxb5a as a critical regulator of spinal cord regeneration in zebrafish by analyzing transcriptional and microenvironmental differences between successful and failed regeneration cases.

Decaying and expanding Erk gradients process memory of skeletal size during zebrafish fin regeneration

The paper quantifies Erk signaling gradients in zebrafish fin regeneration and shows they scale with tissue amputation size to control skeletal regeneration.

Enhancer-directed gene delivery for digit regeneration based on conserved epidermal factors

This paper develops a gene therapy approach for digit regeneration using enhancer-directed delivery of FGF8 to restore impaired regeneration in SP transcription factor knockout mice.

Live visualization of extracellular matrix dynamics during development and regeneration in zebrafish

The paper develops a method to visualize ECM dynamics in zebrafish during development and regeneration, revealing distinct expression patterns and dynamic behaviors of specific ECM proteins.

Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells

Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model

This study investigates DDX3X syndrome using a mouse model, showing that DDX3X regulates cell cycle and translation in neural progenitors, leading to cortical malformations and neurodevelopmental issues.

Identification of enhancer regulatory elements that direct epicardial gene expression during zebrafish heart regeneration

The paper identifies enhancer elements that regulate epicardial gene expression during zebrafish heart regeneration by analyzing transcriptomes and chromatin accessibility.

dagLogo: an R/Bioconductor package for identifying and visualizing differential amino acid group usage in proteomics data

The paper introduces dagLogo, an R/Bioconductor package for identifying and visualizing differential amino acid group usage in proteomics data, showing improved performance in detecting conserved sequence patterns.

Two Contrasting Classes of Nucleolus-Associated Domains in Mouse Fibroblast Heterochromatin

The paper identifies two distinct classes of Nucleolus-Associated Domains (NADs) in mouse fibroblasts using deep sequencing and a new tool, showing differences in chromatin features and gene expression.