Stephen N. Floor

This study uses HiT-FRAP to show that ribosome assembly state affects nucleolar dynamics and morphology through interactions with NPM1.

The paper identifies key residues in G3BPs that drive stress granule formation and gene expression changes under cellular stress, with G3BP2B showing specific roles in ER stress.

The paper quantifies RNA flow across subcellular compartments using TimeLapse-seq and identifies factors influencing mRNA life cycles.

This study shows IGHMBP2 deletion reduces global translation and activates the integrated stress response (ISR) in K562 cells, linking it to neuromuscular disease mechanisms.

This study identifies DDX3X's role in translation by developing HART, a reporter that measures DDX3X-dependent translational activity and reveals structural and functional determinants of its sensitivity.

The paper identifies GC content in coding sequences as a key factor in mRNA stabilization following DDX3X depletion, supported by analysis of RNA-seq data and ENCODE datasets.

The paper introduces REMORA, a method to record RNA-protein interactions on single RNA molecules by using RNA deaminases, and shows competition between PUM1 and PUM2 for RNA binding sites.

The paper shows that inhibiting NMD in FSHD leads to widespread production of truncated RNA-binding proteins, some of which are toxic and can be detected in patient samples.

This study investigates DDX3X syndrome using a mouse model, showing that DDX3X regulates cell cycle and translation in neural progenitors, leading to cortical malformations and neurodevelopmental issues.

This study shows DDX3X and DDX3Y redundantly regulate translation, with DDX3Y compensating for DDX3X loss in human cells, explaining sex-bias in DDX3X-related diseases.

This study identifies mRNAs regulated by DDX3 depletion using ribosome profiling and RNA-seq, showing DDX3 preferentially affects a subset of transcripts with complex 5' UTRs.

The paper shows the Microprocessor complex regulates ribosomal protein synthesis by binding TOP motifs and promoting transcription elongation, linking ribosome biogenesis to cell growth.

This study identifies DDX3X mutations as causing neurodevelopmental disorders by disrupting RNA metabolism and neurogenesis during fetal cortical development.

The paper identifies PTBP1 mRNA isoforms and shows their cell cycle-dependent regulation by eIF3, affecting PTBP1 protein levels and downstream processes.

This study shows that NRDE2 prevents DNA damage accumulation during mitosis under stress by interacting with monomeric nuclear actin, which is critical for genomic integrity.