Abigail Poff

The paper integrates bulk and single-cell RNA-seq data from C. elegans neurons to improve transcript detection and differential gene analysis.

The paper presents an atlas of alternative splicing in C. elegans neurons, identifies novel splicing events, and describes regulatory patterns and networks.

This study investigates DDX3X syndrome using a mouse model, showing that DDX3X regulates cell cycle and translation in neural progenitors, leading to cortical malformations and neurodevelopmental issues.

The paper integrates bulk and single-cell RNA-seq data from C. elegans neurons to improve transcript detection and differential gene analysis.

The paper provides a comprehensive gene expression profile of all 302 neurons in the C. elegans nervous system and identifies cis-regulatory elements and adhesion proteins involved in synaptic specificity.

Transcriptomes of 52,412 neurons resolve 109 of the 118 canonical hermaphrodite neuron classes, and neuropeptide genes separate subtypes inside individual classes.