The Role of ATP Synthase Subunit e (ATP5I) in Mediating the Metabolic and Antiproliferative Effects of Metformin
Guillaume Lefrançois, Emilie Lavallée, Marie‐Camille Rowell, Véronique Bourdeau, Farzaneh Mohebali, Thierry Bertomeu, Ana Maria Duman, Maya Nikolova, Mike Tyers, Simon‐Pierre Gravel, Andreea R. Schmitzer, Gerardo Ferbeyre
This paper identifies ATP5I as a target of metformin, showing its role in mediating metabolic and antiproliferative effects through mitochondrial dysfunction and altered ATP synthase oligomerization.
bioRxiv · Sep 20, 2024 · PreprintCancer Biology