Gerardo Ferbeyre

Targeting ribosome biogenesis sensitizes PARPi-resistant triple-negative breast cancer

This study shows that combining PARPi with ribosome biogenesis inhibitors sensitizes PARPi-resistant triple-negative breast cancer cells and identifies ribosome biogenesis as a therapeutic target.

Lactate-fueled hydride transfer metabolon drives breast cancer metastasis

This study identifies a lactate-fueled metabolon involving LDHB and HTC that promotes breast cancer metastasis by reprogramming NAD metabolism.

SOCS1 expression in prostate epithelial cells is essential for tissue homeostasis and tumor suppression

This study shows that SOCS1 in prostate epithelial cells is crucial for tissue homeostasis and tumor suppression by controlling proliferation, inflammation, and DNA damage response.

Senescent fibroblasts interfere with the tumor immune response in humanized models by inducing neutrophil extracellular traps

This study shows senescent fibroblasts in humanized mouse models promote tumor progression by inducing neutrophil extracellular traps (NETs) that impair immune responses.

Biguanide-PROTACs: Modulating Mitochondrial Proteins in Pancreatic Cancer Cells

This study synthesizes Biguanide-PROTACs and evaluates their activity on pancreatic cancer cells, finding structure-permeability-activity relationships and some AMPK activation.

The Role of ATP Synthase Subunit e (ATP5I) in Mediating the Metabolic and Antiproliferative Effects of Metformin

This paper identifies ATP5I as a target of metformin, showing its role in mediating metabolic and antiproliferative effects through mitochondrial dysfunction and altered ATP synthase oligomerization.

The retinoblastoma tumor suppressor limits ribosomal readthrough during oncogene induced senescence

The paper shows that the retinoblastoma protein (RB) prevents ribosomal readthrough during oncogene-induced senescence, acting as a caretaker tumor suppressor.

Senescence gives insights into the morphogenetic evolution of anamniotes.

The paper identifies senescent cells in transient structures of developing amphibians and fish, suggesting an early evolutionary role of senescence in morphogenesis.