MECOM promotes leukemia progression and inhibits mast cell differentiation through functional competition with GATA2
Kohei Iida, Mayuko Nakanishi, Jakushin Nakahara, Shuhei Asada, Tomoya Isobe, Tomohiro Yabushita, Tsuyoshi Fukushima, Yosuke Tanaka, Manabu Ozawa, Yasuhiro Yamada, Toshio Kitamura, Keita Yamamoto, Susumu Goyama
This study shows that MECOM mutations impair DNA binding and functionally antagonize GATA2, promoting leukemia and inhibiting mast cell differentiation.
Leukemia · May 5, 2026Peer-reviewedMolecular Biology