Tomohiro Yabushita

This study tracks Gfi1 expression dynamics during hematopoietic development and identifies its role in defining EHT and HSC potency.

The paper develops a DNA barcoding-based method to analyze HSC daughter cell pairs, revealing biased division patterns toward symmetric divisions and linking these to molecular features.

This study shows that MECOM mutations impair DNA binding and functionally antagonize GATA2, promoting leukemia and inhibiting mast cell differentiation.

This study identifies Plcl1 as a regulator of calcium dynamics in hematopoietic stem cells, affecting their function during aging and stress.

This study identifies mitotic vulnerabilities in AML cells induced by therapeutic agents, showing increased cytotoxicity during mitosis compared to S/G2 phase arrest.